Surgery-related weight reduction within males reverses androgenic hormone or testosterone insufficiency, research discovers

Low testosterone levels and symptoms of male sexual dysfunction due to obesity may be reversible with weight loss after bariatric surgery, a new study finds.

The results were presented at The Endocrine Society's 93rd Annual Meeting in Boston.

Morbidly obese men have a high prevalence of hypotestosteronenemia, or low testosterone, and of sexual dysfunction, said study co-author Jean-Paul Thissen, MD, PhD, a professor at the University of Louvain in Brussels. It is reassuring that these problems are potentially curable by weight loss.

This study included 75 obese men who .

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a gonorrhea treatment in 1989. By the early 2000s, however, resistance had developed among cases in California and Hawaii and among MSM, prompting CDC to stop recommending ciprofloxacin in those populations. In 2007, CDC stopped recommending it throughout the United States.

And now we’re left with that sole remaining class, the third-generation cephalosporins.

In Black Knight terms, we’re standing on only one leg – and that leg is getting wobbly, as reports of resistance to both oral and injected third-generation cephalosporins are emerging.

What needs to be done?

First, we should expand efforts to track antibiotic resistance in gonorrhea, including development and use of advanced molecular techniques.

Second, we should develop rapid tests that can determine which antibiotics could be used to treat a case of gonorrhea. That could increase the number of antibiotic options potentially available to treat gonorrhea and decrease the likelihood of resistance developing to any one particular antibiotic.

Third, to forestall the emergence of resistance, we should use antibiotics more judiciously.

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Fourth, we should encourage the development of new drugs for gonorrhea and other infections. One clinical trial of new drugs for gonorrhea is underway. More are needed. The Infectious Disease Society of America’s “10 by ‘20” program, which advocates for the development of ten new antibiotics by 2020, is on the right track.

It’s time to start taking gonorrhea prevention and control more seriously, before we end up – like the Black Knight – without a leg to stand on.


[1] There are limited data regarding the correlation between laboratory evidence of reduced susceptibility to azithromycin in gonorrhea cases and clinical response to treatment with azithromycin.

[2] New guidelines from CDC, released in December 2010, now recommend dual treatment for every case of gonorrhea. Details of recommended treatment regimens, which include a third-generation cephalosporin and either azithromycin or doxycyline, are available here.


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